Echinocandins (caspofungin micafungin anidulafungin)
INDICATION
- Invasive candidiasis (resistant to fluconazole/amphotericin B and/or where renal dysfunction is present and amphotericin B cannot be used).
NEMLC RECOMMENDATION
- Approved – Special Access
- Echinocandins approved as a class, with the most affordable agent to be procured.
- The use of echinocandins should be managed through motivation/ appropriate restrictions at facilities, as part of Antimicrobial Stewardship activities. (See addendum – clinical criteria for use)
REVIEW INDICATORS
- Availability of amphotericin B
- Changing resistance patterns
- New evidence
DATE RATIFIED