| Syndrome | Asymptomatic partner | Symptomatic partner |
| VDS |
· Ceftriaxone, IM, 250 mg immediately as a single dose. AND · Metronidazole, oral, 2 g immediately as a single dose. AND · Azithromycin, oral, 1 g as a single dose. |
· Ceftriaxone, IM, 250 mg immediately as a single dose. AND · Metronidazole, oral, 2 g immediately as a single dose. AND · Azithromycin, oral, 1 g as a single dose. PLUS treatment for syndrome present if not included in the above. |
| LAP |
· Ceftriaxone, IM, 250 mg immediately as a single dose. AND · Metronidazole, oral, 2 g immediately as a single dose. AND · Azithromycin, oral, 1 g as a single dose. |
· Ceftriaxone, IM, 250 mg immediately as a single dose. AND · Metronidazole, oral, 2 g immediately as a single dose. AND · Azithromycin, oral, 1 g as a single dose. PLUS treatment for syndrome present if not included in the above. |
| MUS |
· Ceftriaxone, IM, 250 mg immediately as a single dose. AND · Azithromycin, oral, 1 g as a single dose. |
· Ceftriaxone, IM, 250 mg immediately as a single dose. AND · Azithromycin, oral, 1 g as a single dose. · PLUS treatment for syndrome present if not included in the above (see VDS flow chart). |
| Scrotal swelling |
· Ceftriaxone, IM, 250 mg immediately as a single dose. AND · Azithromycin, oral, 1 g as a single dose. |
· Ceftriaxone, IM, 250 mg immediately as a single dose. AND · Azithromycin, oral, 1 g as a single dose. PLUS treatment for syndrome present if not included in the above. |
| GUS |
· Doxycycline, oral, 100 mg 12 hourly for 14 days. Except pregnant women: · Benzathine benzylpenicillin, IM, 2.4 MU immediately as a single dose. o Dissolve benzathine benzylpenicillin, IM, 2.4 MU in 6 mL lidocaine 1% without epinephrine (adrenaline). (If pregnant and benzathine benzylpenicillin is unavailable, see syphilis flow chart). |
· Doxycycline, oral, 100 mg 12 hourly for 14 days. Except pregnant women: · Benzathine benzylpenicillin, IM, 2.4 MU immediately as a single dose. o Dissolve benzathine benzylpenicillin, IM, 2.4 MU in 6 mL lidocaine 1% without epinephrine (adrenaline). PLUS treatment for syndrome present if not included in the above. (If pregnant and benzathine benzylpenicillin is unavailable, see syphilis flow chart). |
| Bubo |
· Azithromycin, oral, 1 g as a single dose. |
· Azithromycin, oral, 1 g as a single dose. PLUS treatment for syndrome present if not included in the above. |