| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
|---|---|---|
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
[7] Syphilis serology (RPR follow-up test in doxycycline-treated patients not recommended): Liu HY, Han Y, Chen XS, Bai L, Guo SP, Li L, Wu P, Yin YP. Comparison of efficacy of treatments for early syphilis: A systematic review and network meta-analysis of randomized controlled trials and observational studies. PLoS One. 2017 Jun 28;12(6):e0180001. https://www.ncbi.nlm.nih.gov/pubmed/28658325
Syphilis serology (RPR follow-up test in doxycycline-treated patients not recommended): Salado-Rasmussen K, Hoffmann S, Cowan S, Jensen JS, Benfield T, Gerstoft J, Katzenstein TL. Serological Response to Treatment of Syphilis with Doxycycline Compared with Penicillin in HIV-infected Individuals. Acta Derm Venereol. 2016 Aug 23;96(6):807-11. https://www.ncbi.nlm.nih.gov/pubmed/26568359
Syphilis serology (RPR follow-up test in doxycycline-treated patients not recommended): Dai T, Qu R, Liu J, Zhou P, Wang Q. Efficacy of Doxycycline in the Treatment of Syphilis. Antimicrob Agents Chemother. 2016 Dec 27;61(1). pii: e01092-16. https://www.ncbi.nlm.nih.gov/pubmed/27795370