Reference 2

Level I Good quality evidence Systematic review of RCTs with
consistent findings
High quality individual RCT
Level II Limited quality patient
orientated evidence
Systematic review of lower quality
studies or studies with inconsistent
findings
Low quality clinical trial
Cohort studies
Case-control studies
Level III Other Consensus guidelines, extrapolations
from bench research, usual practice,
opinion, disease-oriented evidence
(intermediate or physiologic outcomes
only), or case series

[2] Vaginal discharge syndrome – Sexual activity criterion: National Institute for Communicable Diseases. Report on the Sentinel Surveillance of Sexually Transmitted Infection Syndrome Aetiologies and HPV Genotypes among Patients attending Public Health Facilities in South Africa (April 2014 – September 2015), embargoed, to be published.

Vaginal discharge syndrome – speculum examination: National Department of Health. Comprehensive STI Clinical Management Guidelines, draft version.

Clotrimazole, topical: Vaginal discharge syndrome – non-sexually active women (monotherapy syndromic directed management – candidiasis): National Institute for Communicable Diseases. Report on the Sentinel Surveillance of Sexually Transmitted Infection Syndrome Aetiologies and HPV Genotypes among Patients attending Public Health Facilities in South Africa (April 2014 – September 2015), embargoed, to be published.

Metronidazole, oral: Vaginal discharge syndrome – non-sexually active women (monotherapy syndromic directed management – bacterial vaginosis): National Institute for Communicable Diseases. Report on the Sentinel Surveillance of Sexually Transmitted Infection Syndrome Aetiologies and HPV Genotypes among Patients attending Public Health Facilities in South Africa (April 2014 – September 2015), embargoed, to be published.