| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
[1] Ceftriaxone, IM (Neisseria gonorrhoeae): Lewis DA, Sriruttan C, Müller EE, Golparian D, Gumede L, Fick D, de Wet J,Maseko V, Coetzee J, Unemo M. Phenotypic and genetic characterization of the first two cases of extended-spectrum-cephalosporin-resistant Neisseria gonorrhoeae infection in South Africa and association with cefixime treatment failure. J Antimicrob Chemother. 2013 Jun;68(6):1267-70. https://www.ncbi.nlm.nih.gov/pubmed/23416957
Ceftriaxone, IM (Neisseria gonorrhoeae): Lewis DA. Gonorrhoea resistance among men who have sex with men: what’s oral sex got to do with it? South Afr J Epidemiol Infect 2013;28(2):77. https://journals.co.za/content/mp_sajei/28/2/EJC138699
Ceftriaxone, IM (Neisseria gonorrhoeae): Ito M, Yasuda M, Yokoi S, Ito S, Takahashi Y, Ishihara S, Maeda S, Deguchi T. Remarkable increase in central Japan in 2001-2002 of Neisseria gonorrhoeae isolates with decreased susceptibility to penicillin, tetracycline, oral cephalosporins, and fluoroquinolones. Antimicrob Agents Chemother. 2004 Aug;48(8):3185-7. https://www.ncbi.nlm.nih.gov/pubmed/15273147
Ceftriaxone, IM (Neisseria gonorrhoeae): Tanaka M, Nakayama H, Tunoe H, Egashira T, Kanayama A, Saika T, Kobayashi I, Naito S. A remarkable reduction in the susceptibility of Neisseria gonorrhoeae isolates to cephems and the selection of antibiotic regimens for the single-dose treatment of gonococcal infection in Japan. J Infect Chemother. 2002 Mar;8(1):81-6. https://www.ncbi.nlm.nih.gov/pubmed/11957125
Ceftriaxone, IM (Neisseria gonorrhoeae): Yokoi S, Deguchi T, Ozawa T, Yasuda M, Ito S, Kubota Y, Tamaki M, Maeda S. Threat to cefixime treatment for gonorrhea. Emerg Infect Dis. 2007 Aug;13(8):1275-7. https://www.ncbi.nlm.nih.gov/pubmed/17953118
Ceftriaxone, IM (Neisseria gonorrhoeae): Unemo M, Nicholas RA. Emergence of multidrug-resistant, extensively drug-resistant and untreatable gonorrhea. Future Microbiol. 2012 Dec;7(12):1401-22. https://www.ncbi.nlm.nih.gov/pubmed/23231489
Ceftriaxone, IM (Neisseria gonorrhoeae): Zhao S, Duncan M, Tomberg J, Davies C, Unemo M, Nicholas RA. Genetics of chromosomally mediated intermediate resistance to ceftriaxone and cefixime in Neisseria gonorrhoeae. Antimicrob Agents Chemother. 2009 Sep;53(9):3744-51. https://www.ncbi.nlm.nih.gov/pubmed/19528266
Ceftriaxone, IM (Neisseria gonorrhoeae): Chisholm SA, Mouton JW, Lewis DA, Nichols T, Ison CA, Livermore DM.
Cephalosporin MIC creep among gonococci: time for a pharmacodynamic rethink? J Antimicrob Chemother. 2010 Oct;65(10):2141-8. https://www.ncbi.nlm.nih.gov/pubmed/20693173
Ceftriaxone, IM (Neisseria gonorrhoeae): Contract circular RT301-2017: Ceftriaxone 250 mg, parenteral formulation.