| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
[8] Salbutamol MDI (paediatrics): Benito-Fernández J, González-Balenciaga M, Capapé-Zache S, Vázquez-Ronco MA, Mintegi-Raso S. Salbutamol via metered-dose inhaler with spacer versus nebulization for acute treatment of pediatric asthma in the emergency department. PediatrEmerg Care. 2004 Oct;20(10):656-9. https://www.ncbi.nlm.nih.gov/pubmed/15454738
Salbutamol MDI (paediatrics): National Department of Health, Essential Drugs Programme:: Paediatric Hospital Level STGs and EML, 2017. http://www.health.gov.za/