| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
[3] Intermittent iron supplementation: Moretti D, Goede JS, Zeder C, et al. Oral iron supplements increase hepcidin and decrease iron absorption from daily or twice-daily doses in iron-depleted young women. Blood. 2015 Oct 22;126(17):1981-9. https://www.ncbi.nlm.nih.gov/pubmed/26289639
Intermittent iron supplementation: Stoffel NU, Cercamondi CI, Brittenham G, et al. Iron absorption from oral iron supplements given on consecutive versus alternate days and as single morning doses versus twice-daily split dosing in iron-depleted women: two open-label, randomised controlled trials. Lancet Haematol. 2017 Nov;4(11):e524-e533. https://www.ncbi.nlm.nih.gov/pubmed/29032957
Intermittent iron supplementation: Pena-Rosas JP, De-Regil LM, Gomez Malave H, Flores-Urrutia MC, Dowswell T. Intermittent oral iron supplementation during pregnancy. The Cochrane database of systematic reviews. 2015(10):CD009997. https://www.ncbi.nlm.nih.gov/pubmed/26482110
Intermittent iron supplementation: Rimon E, Kagansky N, Kagansky M, Mechnick L, Mashiah T, Namir M, Levy S. Are we giving too much iron? Low-dose iron therapy is effective in octogenarians. Am J Med. 2005 Oct;118(10):1142-7. https://www.ncbi.nlm.nih.gov/pubmed/16194646
Intermittent iron supplementation: National Department of Health, Essential Drugs Programme: Adult Hospital Level STGs and EML, 2019. http://www.health.gov.za/