| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
[24] Sedation algorithm (stepwise approach): NICE. The short-term management of disturbed/violent behaviour in in-patient psychiatric settings and emergency departments, NICE clinical guideline 25, February 2005. Available at: www.nice.org.uk/cg25
Sedation algorithm (stepwise approach): Wilson MP, Pepper D, Currier GW, Holloman GH Jr, Feifel D. The psychopharmacology of agitation: consensus statement of the American association for emergency psychiatry project Beta psychopharmacology workgroup. West J Emerg Med. 2012 Feb;13(1):26-34. http://www.ncbi.nlm.nih.gov/pubmed/22461918