Reference 17

Level I Good quality evidence Systematic review of RCTs with
consistent findings
High quality individual RCT
Level II Limited quality patient
orientated evidence
Systematic review of lower quality
studies or studies with inconsistent
findings
Low quality clinical trial
Cohort studies
Case-control studies
Level III Other Consensus guidelines, extrapolations
from bench research, usual practice,
opinion, disease-oriented evidence
(intermediate or physiologic outcomes
only), or case series

[17] Morphine syrup (Children: palliative dyspnoea): Johnston DL, Hentz TA, Friedman DL. Pediatric palliative care. J Pediatr Pharmacol Ther. 2005 Oct;10(4):200-14. https://www.ncbi.nlm.nih.gov/pubmed/23118638

Morphine syrup (Children: palliative dyspnoea): National Department of Health: Affordable Medicines, EDP- PHC. Medicine Review: Morphine, oral for palliative dyspnoea in adults and children, September 2017. http://www.health.gov.za/