| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
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MIdazolam, buccal (children-status epilepticus): McMullan J, Sasson C, Pancioli A, Silbergleit R. Midazolam versus diazepam for the treatment of status epilepticus in children and young adults: a meta-analysis. Acad Emerg Med. 2010 Jun;17(6):575-82. http://www.ncbi.nlm.nih.gov/pubmed/20624136
Midazolam, buccal (children-status epilepticus): McIntyre J, Robertson S, Norris E, Appleton R, Whitehouse WP, Phillips B, Martland T, Berry K, Collier J, Smith S, Choonara I. Safety and efficacy of buccal midazolam versus rectal diazepam for emergency treatment of seizures in children: a randomised controlled trial. Lancet. 2005 Jul 16-22;366(9481):205-10. http://www.ncbi.nlm.nih.gov/pubmed/16023510
Midazolam, buccal (children-status epilepticus): Mpimbaza A, Ndeezi G, Staedke S, Rosenthal PJ, Byarugaba J. Comparison of buccal midazolam with rectal diazepam in the treatment of prolonged seizures in Ugandan children: a randomized clinical trial. Pediatrics. 2008; 121:e58–64. http://www.ncbi.nlm.nih.gov/pubmed/18166545
Midazolam, buccal (children-status epilepticus): Scott RC, Besag FM, Neville BG. Buccal midazolam and rectal diazepam for treatment of prolonged seizures in childhood and adolescence: a randomised trial. Lancet.1999; 353:623–6. http://www.ncbi.nlm.nih.gov/pubmed/10030327
MIdazolam, buccal (children-second dose): National Department of Health: Affordable Medicines, EDP-PHC level. Medicine review: Buccal midazolam (repeat dose) for status epilepticus in children - review update, 25 May 2017. http://health.gov.za/
MIdazolam, buccal (children-second dose): Smith R, Brown J. Midazolam for status epilepticus. Aust Prescr. 2017 Feb;40(1):23-25. https://www.ncbi.nlm.nih.gov/pubmed/28246432
Midazolam, buccal (children-second dose): World Health Organisation. mhGAP Intervention Guide Mental Health Gap Action Programme for mental, neurological and substance use disorders in non-specialized health settings, version 2.0 Geneva: World Health Organization; 2016. http://www.who.int/mental_health/mhgap/mhGAP_intervention_guide_02/en/
Midazolam, buccal (children-second dose): National Institute for Health and Care Excellence. Epilepsies: diagnosis and management Clinical guideline [CG137], 2012. https://www.nice.org.uk/guidance/cg137