| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
[2] Aspirin, oral (thrombolytic interaction): Luo S, Zhuang M, Zeng W, Tao J. Intravenous Thrombolysis for Acute Ischemic Stroke in Patients Receiving Antiplatelet Therapy: A Systematic Review and Meta-analysis of 19 Studies. J Am Heart Assoc. 2016 May 20;5(5). pii: e003242. https://www.ncbi.nlm.nih.gov/pubmed/27207999
Aspirin, oral (thrombolytic interaction): Mousa SA, Forsythe MS, Bozarth JM, Reilly TM. Effect of single oral dose of aspirin on human platelet functions and plasma plasminogen activator inhibitor-1. Cardiology. 1993;83(5-6):367-73. https://www.ncbi.nlm.nih.gov/pubmed/8111770
Aspirin, oral (pre-referral dose in acute stroke): National Department of Health: Affordable Medicines, EDP- Primary Health Care Level. Medicine Review: Aspirin, pre-referral dose for acute stroke, March 2018. http://www.health.gov.za/