| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
[41] Hydrochlorothiazide, oral (1st line treatment - hypertension without compelling indications): ALLHAT officers and co-ordinators for the ALLHAT collaborative research group. The antihypertensive and lipid lowering treatment to prevent heart attack trial. Major outcomes in moderately hypercholesterolemic, hypertensive patients randomized to pravastatin vs usual care: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT-LLT). JAMA 2002; 288:2998–3007. https://www.ncbi.nlm.nih.gov/pubmed/12479764
Hydrochlorothiazide, oral (1st line treatment - hypertension without compelling indications): de Leeuw PW, Ruilope LM, Palmer CR, Brown MJ, Castaigne A, Mancia G, Rosenthal T, Wagener G. Clinical significance of renal function in hypertensive patients at high risk: results from the INSIGHT trial. Arch Intern Med. 2004 Dec 13-27;164(22):2459-64. https://www.ncbi.nlm.nih.gov/pubmed/15596636
Hydrochlorothiazide, oral (1st line treatment - hypertension without compelling indications): Black HR, Elliott WJ, Grandits G, Grambsch P, Lucente T, White WB, Neaton JD, Grimm RH Jr, Hansson L, Lacourciere Y, Muller J, Sleight P, Weber MA, Williams G, Wittes J, Zanchetti A, Anders RJ; CONVINCE Research Group. Principal results of the Controlled Onset Verapamil Investigation of Cardiovascular End Points (CONVINCE) trial. JAMA. 2003 Apr 23-30;289(16):2073-82. https://www.ncbi.nlm.nih.gov/pubmed/12709465
Hydrochlorothiazide, oral (1st line treatment - hypertension without compelling indications): Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). 2013 ESH/ESC Guidelines for the management of arterial hypertension Journal of Hypertension. 2013, 31:1281–1357. https://www.ncbi.nlm.nih.gov/pubmed/24107724
Hydrochlorothiazide, oral (1st line treatment - hypertension without compelling indications): Eighth Joint National Committee (JNC 8) 2014 Evidence-Based Guidelines for the Management of High Blood Pressure in Adults, 2014. http://www.aafp.org/patient-care/clinical-recommendations/all/highbloodpressure.html