B20-B24
DESCRIPTION
An infant < 1 month of age, in whom HIV infection has been confirmed with 2 appropriate tests. For confirmation of HIV infection see Human immunodeficiency virus infections .
MEDICINE TREATMENT
This treatment protocol is meant as a guide, and there is allowance for flexibility after discussion with an expert.
ARV drug dosing chart:
for children < 28 days of age and weighing ≥ 2.5 kg at birth
| Lamivudine (3TC) |
Zidovudine (AZT) |
Nevirapine (NVP) |
||||
|---|---|---|---|---|---|---|
|
Target dose |
2 mg/kg/dose TWICE daily (BD) |
4 mg/kg/dose TWICE daily (BD) |
6 mg/kg/dose TWICE daily (BD) |
|||
|
Available formulation |
10 mg/ml | 10 mg/ml | 10 mg/ml | |||
| Weight (kg) |
Dose in ml |
Dose in mg |
Dose in ml |
Dose in mg |
Dose in ml |
Dose in mg |
| ≥2.5-<3.0 | 0.6ml BD | 6mg BD | 1.2ml BD | 12mg BD | 1.8ml BD | 18mg BD |
| ≥3.0-<3.5 | 0.7ml BD | 7mg BD | 1.4ml BD | 14mg BD | 2.1ml BD | 21mg BD |
| ≥3.5-<4.0 | 0.8ml BD | 8mg BD | 1.6ml BD | 16mg BD | 2.4ml BD | 24mg BD |
| ≥4.0-<4.5 | 0.9ml BD | 9mg BD | 1.8ml BD | 18mg BD | 2.7ml BD | 27mg BD |
| ≥4.5-<5.5 | 1.0ml BD | 10mg BD | 2.0ml BD | 20mg BD | 3.0ml BD | 30mg BD |
| ≥5.5-<6.5 | 1.2ml BD | 12mg BD | 2.4ml BD | 24mg BD | 3.6ml BD | 36mg BD |
Caregivers who will be administering ARV medication to the child must be supplied with a syringe (1ml or 2ml) for each of the 3 ARVs and shown how to prepare and administer the correct dose. If possible, bottles and syringes should be colour coded with stickers and a sticker of the relevant colour used to mark the correct dose on the syringe.