DESCRIPTION
Impairment of bile formation and/or bile flow which may present with pruritis and/or jaundice. It is classified as intrahepatic (e.g. chronic hepatitis, paucity of bile ducts) or extrahepatic (e.g. biliary atresia).
GENERAL AND SUPPORTIVE MEASURES
Diet supplemented with medium-chain triglycerides.
MEDICINE TREATMENT
For pruritus of cholestasis:
- Colestyramine, oral, 240 mg/kg/day in 3 divided doses with meals.
- Mix with water or other fluids.
- Other medications should be given 1 hour before or 4-6 hours after colestyramine use.
For sedation:
Chlorphenamine, oral, 0.1 mg/kg/dose up to 6 hourly.