| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
[6] Amphotericin B, IV: Rex JH, Bennett JE, Sugar AM, Pappas PG, van der Horst CM, Edwards JE, Washburn RG, Scheld WM, Karchmer AW, Dine AP, et al. A randomized trial comparing fluconazole with amphotericin B for the treatment of candidemia in patients without neutropenia.Candidemia Study Group and the National Institute. N EnglJ Med. 1994 Nov 17;331(20):1325-30. http://www.ncbi.nlm.nih.gov/pubmed/7935701
Amphotericin B, IV: Phillips P, Shafran S, Garber G, Rotstein C, Smaill F, Fong I, Salit I, Miller M, Williams K, Conly JM, Singer J, Ioannou S. Multicenter randomized trial of fluconazole versus amphotericin B for treatment of candidemia in non-neutropenic patients. Canadian Candidemia Study Group. Eur J ClinMicrobiol Infect Dis. 1997 May;16(5):337-45. http://www.ncbi.nlm.nih.gov/pubmed/9228472
Amphotericin B, IV: Anaissie EJ, Darouiche RO, Abi-Said D, Uzun O, Mera J, Gentry LO, Williams T, Kontoyiannis DP, Karl CL, Bodey GP. Management of invasive candidal infections: results of a prospective, randomized, multicenter study of fluconazole versus amphotericin B and review of the literature. Clin Infect Dis. 1996 Nov;23(5):964-72. http://www.ncbi.nlm.nih.gov/pubmed/8922787
Amphotericin B, IV: Takesue Y, Ueda T, Mikamo H, Oda S, Takakura S, Kitagawa Y, Kohno S; ACTIONs Project. Management bundles for candidaemia: the impact of compliance on clinical outcomes. J AntimicrobChemother. 2015 Feb;70(2):587-93. http://www.ncbi.nlm.nih.gov/pubmed/25326087
Amphotericin B, IV: WHO. Diagnosis, Prevention and Management of Cryptococcal disease in HIV- infected Adults, Adolescents and children – 2011. Geneva: World Health Organization; 2011.http://www.who.int/en/
Amphotericin B, IV: Atsmon J, Dolev E. Drug-induced hypomagnesaemia : scope and management. Drug Saf. 2005;28(9):763-88. http://www.ncbi.nlm.nih.gov/pubmed/16119971
Amphotericin B, IV: WHO. Rapid advice: diagnosis, prevention and management of cryptococcal disease in HIV-infected adults, adolescents and children. 2011 [Online][Accessed June 2015] http://www.ncbi.nlm.nih.gov/books/NBK299520/pdf/Bookshelf_NBK299520.pdf