| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
[17] Polyvalent pneumococcal vaccine revaccination – splenectomy: Rutherford EJ, Livengood J, Higginbotham M, Miles WS, Koestner J, Edwards KM, Sharp KW, Morris JA Jr. Efficacy and safety of pneumococcal revaccination after splenectomy for trauma. J Trauma. 1995 Sep;39(3):448-52. http://www.ncbi.nlm.nih.gov/pubmed/7473907
Polyvalent pneumococcal vaccine revaccination – splenectomy (dosing schedule): ACIP Practice Guidelines - CDC. Morbidity and Mortality Weekly Report, October 12, 2012, Vol 61, No 40. http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6140a4.htm?s_cid=mm6140a4_w