| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
[1] Ceftriaxone (1000mg - MUS): Fifer H, Natarajan U, Jones L, Alexander S, Hughes G, Golparian D, Unemo M. Failure of Dual Antimicrobial Therapy in Treatment of Gonorrhea. NEJM 2016. 374;25: 2504-2506.
Ceftriaxone (1000mg - MUS): Bignell C, Unemo M; European STI Guidelines Editorial Board. 2012 European
guideline on the diagnosis and treatment of gonorrhoea in adults. Int J STD AIDS.2013 Feb;24(2):85-92. https://www.ncbi.nlm.nih.gov/pubmed/24400344