| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
[9] Naloxone, IV (reversal agent for opioid toxicity): The South African Society of Anaesthesiologists. South African Society of Anaesthesiologists Sedation Guidelines, 2015. South Afr J AnaesthAnalg 2015;21(2)S1-S36.http://www.sasaweb.com/content/images/SAJAA_V21N2_1665_Sedation_Guideline.pdf