| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
[47] Levofloxacin, oral (with rifampicin, ethambutamol, pyrazinamide): National Department of Health: Affordable Medicines, EDP-Adult Hospital level. Medicine Review: Levofloxacin, oral (in addition to rifampicin, pyrazinamide, and ethambutol) for isoniazid-resistant tuberculosis, September 2019. http://www.health.gov.za/
Levofloxacin, oral (with rifampicin, ethambutamol, pyrazinamide): Fregonese F, Ahuja SD, Akkerman OW, Arakaki-Sanchez D, Ayakaka I, Baghaei P, et al. Comparison of different treatments for isoniazid-resistant tuberculosis: an individual patient data meta-analysis. Lancet Respir Med. 2018;6(4):265-75. https://www.ncbi.nlm.nih.gov/pubmed/29595509
Levofloxacin, oral (with rifampicin, ethambutamol, pyrazinamide): World Health Organization. WHO Consolidated Guidelines on Drug-resistant Tuberculosis Treatment 2019 [Available from: https://www.who.int/tb/publications/2019/consolidated-guidelines-drug-resistant-TB-treatment/en/