Isoniazid monoresistant TB

A15.0-3/A15.7-8/A16.0-2/A16.3-4/A16.7-9/B20.0 + (U50.00-01/U50.10-11)

MEDICINE TREATMENT

Confirmed INH monoresistant TB:

  • Rifampicin, oral, 10 mg/kg daily.

AND

  • Ethambutol, oral, 15 mg/kg daily.

AND

  • Pyrazinamide, oral, 25 mg/kg daily.

AND

  • Levofloxacin, oral, daily.
    • 30–50 kg: 750 mg
    • >50 kg: 1000 mg

LoEIII [47]

Where single medicines are not available or the pill burden is too high a fixed dose combination of RHZE dosed as per weight may be used, and levofloxacin added to this.

Treatment should be given for at least 6 months.