| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
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Lamotrigine, oral (depressive residual symptoms and prevention of depressive relapse): Bipolar disorder management: National Department of Health: Affordable Medicines, EDP-Adult Hospital level. Medicine Review: Overview of management of bipolar disorders in adults, March 2019. http://www.health.gov.za/
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