| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
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Quetiapine, oral (depressive residual symptoms): Butler M, Urosevic S, Desai P, Sponheim SR, Popp J, Nelson VA, et al. Treatment for Bipolar Disorder in Adults: A Systematic Review. AHRQ Comparative Effectiveness Reviews. Rockville (MD) 2018. https://www.ncbi.nlm.nih.gov/books/NBK532183/
Quetiapine, oral (depressive residual symptoms): Miura T, Noma H, Furukawa TA, Mitsuyasu H, Tanaka S, Stockton S, et al. Comparative efficacy and tolerability of pharmacological treatments in the maintenance treatment of bipolar disorder: a systematic review and network meta-analysis. Lancet Psychiatry. 2014;1(5):351-9. https://www.ncbi.nlm.nih.gov/pubmed/26360999
Quetiapine, oral (depressive residual symptoms): Lindstrom L, Lindstrom E, Nilsson M, Hoistad M. Maintenance therapy with second generation antipsychotics for bipolar disorder - A systematic review and meta-analysis. Journal of affective disorders. 2017;213:138-50. https://www.ncbi.nlm.nih.gov/pubmed/28222360
Quetiapine, oral (depressive residual symptoms): Kessing LV, Bauer M, Nolen WA, Severus E, Goodwin GM, Geddes J. Effectiveness of maintenance therapy of lithium vs other mood stabilizers in monotherapy and in combinations: a systematic review of evidence from observational studies. Bipolar Disord. 2018 Feb 14. https://www.ncbi.nlm.nih.gov/pubmed/29441712
Quetiapine, oral (dosing for treatment of depression in bipolar disorder): British National Formulary, 78th edition (September 2019-March 2020).