| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
[29] Lamotrogine, oral (risk in pregnancy/breastfeeding): South African Medicines Formulary. 12th Edition. Division of Clinical Pharmacology. University of Cape Town. 2016.
Lamotrogine, oral (risk in pregnancy/breastfeeding): Wesseloo R, Liu X, Clark CT, Kushner SA, Munk-Olsen T, Bergink V. Risk of postpartum episodes in women with bipolar disorder after lamotrigine or lithium use during pregnancy: A population-based cohort study. J Affect Disord. 2017 Aug 15;218:394-397. https://www.ncbi.nlm.nih.gov/pubmed/28501739
Lamotrogine, oral (risk in pregnancy/breastfeeding): Ding Y, Tan X, Zhang S, Guo Y. Pharmacokinetic changes and therapeutic drug monitoring of lamotrigine during pregnancy. Brain Behav. 2019 Jul;9(7):e01315. https://www.ncbi.nlm.nih.gov/pubmed/31104352