| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
[23] N-Acetycysteine,IV (dosing regimen): Wong A, Graudins A. Simplification of the standard three-bag intravenous
acetylcysteine regimen for paracetamol poisoning results in a lower incidence of
adverse drug reactions. Clin Toxicol (Phila). 2016;54(2):115-9. https://www.ncbi.nlm.nih.gov/pubmed/26594846