Reference 22

Level I Good quality evidence Systematic review of RCTs with
consistent findings
High quality individual RCT
Level II Limited quality patient
orientated evidence
Systematic review of lower quality
studies or studies with inconsistent
findings
Low quality clinical trial
Cohort studies
Case-control studies
Level III Other Consensus guidelines, extrapolations
from bench research, usual practice,
opinion, disease-oriented evidence
(intermediate or physiologic outcomes
only), or case series

[22] Paracetamol overdosing – repeated subtherapeutic ingestion: Chiew AL, Fountain JS, Graudins A, Isbister GK, Reith D, Buckley NA. Summary statement: new guidelines for the management of paracetamol poisoning in

Australia and New Zealand. Med J Aust. 2015 Sep 7;203(5):215-8. Erratum in: Med J Aust. 2015 Oct 19;203(8):320. Med J Aust. 2016 Aug 15;205(4):167. https://www.ncbi.nlm.nih.gov/pubmed/26852051