| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
[3] Dexamethasone, IV: Kumar A, Weber MH, Gokaslan Z, Wolinsky JP, Schmidt M, Rhines L, Fehlings MG, Laufer I, Sciubba DM, Clarke MJ, Sundaresan N, Verlaan JJ, Sahgal A, Chou D, Fisher CG. Metastatic Spinal Cord Compression and Steroid Treatment: A Systematic Review. Clin Spine Surg. 2017 May;30(4):156-163. https://www.ncbi.nlm.nih.gov/pubmed/28437329
Dexamethasone, IV: Greenberg HS, Kim JH, Posner JB. Epidural spinal cord compression from metastatic tumor: results with a new treatment protocol. Ann Neurol. 1980;8:361-366. https://www.ncbi.nlm.nih.gov/pubmed/7436380
Dexamethasone, IV: Vecht CJ, Haaxma-Reiche H, van Putten WL, de Visser M, Vries EP, Twijnstra A. Initial bolus of conventional versus high-dose dexamethasone in metastatic spinal cord compression. Neurology. 1989 Sep;39(9):1255-7. https://www.ncbi.nlm.nih.gov/pubmed/2771077
Dexamethasone, IV: National Department of Health: Affordable Medicines, EDP-Adult Hospital level. Historically accepted use-review: Dexamethasone IV for metastatic spinal cord compression, March 2019. http://www.health.gov.za/
Dexamethasone, IV (dosing): National Institute for Health and Care Excellence. Clinical Guidelines: Metastatic spinal cord compression in adults: risk assessment, diagnosis and management, November 2008.