| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
[39] Misoprostol: Essential Steps in Managing Obstetric Emergencies (ESMOE), facilitator’s guide.
Misoprostol: Hofmeyr GJ, GĂĽlmezoglu AM, Novikova N, Linder V, Ferreira S, Piaggio G. Misoprostol to prevent and treat postpartum haemorrhage: a systematic review and meta-analysis of maternal deaths and dose-related effects. Bull World Health Organ. 2009 Sep;87(9):666-77. http://www.ncbi.nlm.nih.gov/pubmed/19784446
Misoprostol: Department of Health, Republic of South Africa. 2015. Guidelines for Maternity care in South Africa, 5th edition. http://www.health.gov.za/
Misoprostol: International Federation Of Gynecology And Obstetrics. Treatment of postpartum hemorrhage with misoprostol. Int J Gynaecol Obstet. 2012 Dec;119(3):215-6. http://www.ncbi.nlm.nih.gov/pubmed/23036964