| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
[38] Tranexamic acid, IV: WOMAN Trial Collaborators. Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial. Lancet 2017; 6736(17)30638-4. https://www.ncbi.nlm.nih.gov/pubmed/28456509
Tranexamic acid, IV: National Department of Health: Affordable Medicines, EDP-Adult Hospital level. Medicine Review: Tranexamic acid, IV, for management of post partum haemmhorhage in pregnant women, 11 October 2017. http://www.health.gov.za/