| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
[12] Methyldopa, oral (dosing): South African Medicines Formulary. 12th Edition. Division of Clinical Pharmacology. University of Cape Town, 2016.
Methyldopa, oral (dosing): Wright JM, Orozco-Gonzalez M, Polak G, Dollery CT. Duration of effect of single daily dose methyldopa therapy. Br J Clin Pharmacol. 1982 Jun;13(6):847-54. https://www.ncbi.nlm.nih.gov/pubmed/7093115