Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
[19] Haloperidol (risk in dementia): Ma H, Huang Y, Cong Z, Wang Y, Jiang W, Gao S, Zhu G. The efficacy and safety of atypical antipsychotics for the treatment of dementia: a meta-analysis of randomized placebo-controlled trials. J Alzheimers Dis. 2014;42(3):915-37. https://www.ncbi.nlm.nih.gov/pubmed/25024323
Haloperidol (risk in dementia): National Institute for Health and Clinical Excellence. Guideline - Dementia: assessment, management and support for people living with dementia and their carers, 20 June 2018. https://www.nice.org.uk/guidance/ng97
Haloperidol (risk in dementia): South African Medicines Formulary, 12th Edition. Division of Clinical Pharmacology. University of Cape Town, 2016.