| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
[6] Haloperidol, parenteral (subcutaneous administration): Franken LG, Mathot RAA, Masman AD, Baar FPM, Tibboel D, van Gelder T, Koch BCP, de Winter BCM. Population pharmacokinetics of haloperidol in terminally ill adult patients. Eur J Clin Pharmacol. 2017 Oct;73(10):1271-1277. https://www.ncbi.nlm.nih.gov/pubmed/28681176
Haloperidol, parenteral (subcutaneous administration): Doyle D, Woodruff R. The IAHPC Manual of Palliative Care. 3rd ed. IAHPC Press, 2013. Available from: https://hospicecare.com/what-we-do/publications/manual-of-palliative-care/ [Accessed August 2019]