| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
[4] Bisacodyl suppository: Canadian Agency for Drugs and Technologies in Health (CADTH). Rapid response report ‐ Routine Bowel Care for Patients in Long‐Term or Palliative Care: Guidelines; 2015 Dec 7. [Internet]. Canadian [cited 2017 October 30]. Available from:
Bisacodyl suppository: Larkin PJ ,Sykes NP, Centeno C, Ellershaw JE, Elsner F, Eugene B, Gootjes JRG, Naba M, Noguera IA, Ripamonti C, Zucco F, Zuurmond WWA .The management of constipation in palliative care: clinical practice recommendations Palliative Medicine. Vol 22, Issue 7, pp.796 – 807. http://dx.doi.org/10.1177%2F0269216308096908
Bisacodyl suppository: National Department of Health: Affordable Medicines, EDP-Primary Health Care. Medicine Review: Bisacodyl suppository in palliative care, 29 August 2017. http://www.health.gov.za/