| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
[24] Hyoscine butylbromide, SC/IM, (respiratory secretions): National Department of Health: Affordable Medicines, EDP-Adult Hospital Level. Medicine Review: Hyoscine butylbromide for management of respiratory secretions in adult palliative care patients, December 2017. http://www.health.gov.za/
Hyoscine butylbromide, SC/IM, (respiratory secretions): NICE guideline: Care of dying adults in the last days of life, 16 December 2015. Available at: https://www.nice.org.uk/guidance/ng31
Hyoscine butylbromide, SC/IM, (respiratory secretions): NHS Lanarkshire Palliative Care Guidelines, March 2012. [Internet] [Accessed January 2018] Available at: http://www.nhslanarkshire.org.uk/Services/PalliativeCare/Documents/NHS%20Lanarkshire%20Palliative%20Care%20Guidelines.pdf
Hyoscine butylbromide, SC/IM, (respiratory secretions): Waitemata District Health Board Palliative Care Guidelines: Hyoscine N-Butylbromide, subcutaneous, April 2016. [Internet] [Accessed January 2018] Available at: http://www.waitematadhb.govt.nz/health-professionals/medicines/palliative-care-guidelines/