| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
[18] Haloperidol, oral/IV/SC (delirium): Candy B, Jackson KC, Jones L, Leurent B, Tookman A, King M. Drug therapy for delirium in terminally ill adult patients. Cochrane Database Syst Rev. 2012 Nov 14;11:CD004770. https://www.ncbi.nlm.nih.gov/pubmed/23152226
Haloperidol, oral/IV/SC (delirium): Grassi L, Caraceni A, Mitchell AJ, Nanni MG, Berardi MA, Caruso R, Riba M. Management of delirium in palliative care: a review. Curr Psychiatry Rep. 2015 Mar;17(3):550. https://www.ncbi.nlm.nih.gov/pubmed/25663153
Haloperidol, oral/IV/SC (delirium): BCGuidelines.ca. Palliative Care for the Patient with Incurable Cancer or Advanced Disease - Part 2: Pain and Symptom Management, 22 February 2017 [Internet] [cited 23 November 2017]. Available at: https://www2.gov.bc.ca/gov/content/health/practitioner-professional-resources/bc-guidelines/palliative-pain-management
Haloperidol, oral/IV/SC (delirium): Agar MR, Lawlor PG, Quinn S, Draper B, Caplan GA, Rowett D, Sanderson C, Hardy J, Le B, Eckermann S, McCaffrey N, Devilee L, Fazekas B, Hill M, Currow DC. Efficacy of Oral Risperidone, Haloperidol, or Placebo for Symptoms of Delirium Among Patients in Palliative Care: A Randomized Clinical Trial. JAMA Intern Med. 2017 Jan 1;177(1):34-42. https://www.ncbi.nlm.nih.gov/pubmed/27918778