Z79.2
TB occurs more commonly in HIV-infected patients. IPT is an effective intervention for reducing the incidence of TB in HIV-infected patients.
Eligibility
All HIV-infected patients, irrespective of CD4 count and ART status.
Exclusions
- Suspected or confirmed TB
- HIV-infected, Tuberculin Skin Test (TST) negative, Pre-ART
- Liver Disease
- Peripheral neuropathy
- Alcohol abusers
- Previous MDR- or XDR-TB
Note:
- TB must be excluded prior to initiating IPT by screening for the following:
- Cough (any duration)
- Weight loss
- Fever
- Night sweats
- IPT should not be initiated in patients if any of the above is present. These patients require further investigation for active TB.
Duration of IPT
| TST POSITIVE | TST NEGATIVE | TST NOT AVAILABLE | |
|---|---|---|---|
|
Patients not on ART |
36 months Continue IPT, when ART is initiated |
not indicated | 6 months |
| On ART | 36 months | 12 months | 12 months |
MEDICINE TREATMENT
- Isoniazid, oral 5 mg/kg/day (maximum 300 mg daily)
AND
- Pyridoxine, oral 25 mg daily.