| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
[37] Bisphosphonates, oral (therapeutic class): Davis S, Martyn-St James M, Sanderson J, Stevens J, Goka E, Rawdin A, et al. A systematic review and economic evaluation of bisphosphonates for the prevention of fragility fractures. Health Technol Assess 2016;20(78). https://www.ncbi.nlm.nih.gov/pubmed/27801641
Bisphosphonates, oral (therapeutic class): National Department of Health: Affordable Medicines, EDP-Adult Hospital level. Medicine Review: Bisphosphonates, oral therapeutic class for secondary prevention of fragility fractures, 31 October 2017. http://www.health.gov.za/
Bisphosphonates, oral (primary prevention of glucocorticoid-induced bone loss): Allen CS, Yeung JH, Vandermeer B, Homik J. Bisphosphonates for steroid-induced osteoporosis. Cochrane Database Syst Rev. 2016 Oct 5;10:CD001347. https://www.ncbi.nlm.nih.gov/pubmed/27706804