| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
[9] Aciclovir, IV: Cernik C, Gallina K, Brodell RT. The treatment of herpes simplex infections:an evidence-based review. Arch Intern Med. 2008 Jun 9;168(11):1137-44.http://www.ncbi.nlm.nih.gov/pubmed/18541820
Aciclovir, IV: South African Medicines Formulary. 12th Edition. Division of Clinical Pharmacology. University of Cape Town, 2016.