| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
[7] Immunosuppresive therapy (e.g. Azathioprine): Hitzig WH, Massimo L. Treatment of autoimmune hemolytic anemia in children with azathioprine (imuran). Blood. 1966 Dec;28(6):840-50. http://www.ncbi.nlm.nih.gov/pubmed/5959475
Immunosuppresive therapy (e.g. Azathioprine): Worlledge SM, Brain MC, Cooper AC, Hobbs JR, Dacie JV. Immmunosuppressive drugs in the treatment of autoimmune haemolytic anaemia. Proc R Soc Med. 1968 Dec
12;61(12):1312-5. http://www.ncbi.nlm.nih.gov/pubmed/4177973
Low molecular weight heparin (first line option - treatment): National Department of Health: Affordable Medicines, EDP- Adult Hospital Level. Cost-effectiveness and budget impact analyses: Fondaparinux for the treatment of venous thromboembolism in hospitalised patients in the South African public health system, April 2018. http://www.health.gov.za/