| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
[20] Lyophilised plasma: Bindi ML, Miccoli M, Marietta M, Meacci L, Esposito M, Bisà M, Mozzo R, Mazzoni A, Baggiani A, Scatena F, Filipponi F, Biancofiore G. Solvent detergent vs. fresh frozen plasma in cirrhotic patients undergoing liver transplant surgery: a prospective randomized control study. Vox Sang. 2013 Aug;105(2):137-43. http://www.ncbi.nlm.nih.gov/pubmed/23448618
Lyophilised plasma: Lerner RG, Nelson J, Sorcia E, Grima K, Kancherla RR, Zarou-Naimo CM, Pehta JC. Evaluation of solvent/detergent-treated plasma in patients with a prolonged prothrombin time. Vox Sang. 2000;79(3):161-7. http://www.ncbi.nlm.nih.gov/pubmed/11111235
Lyophilised plasma: Williamson LM, Llewelyn CA, Fisher NC, Allain JP, Bellamy MC, Baglin TP, Freeman J, Klinck JR, Ala FA, Smith N, Neuberger J, Wreghitt TG. A randomized trial of solvent/detergent-treated and standard fresh-frozen plasma in the coagulopathy of liver disease and liver transplantation. Transfusion. 1999 Nov-Dec;39(11-12):1227-34. http://www.ncbi.nlm.nih.gov/pubmed/10604250
Lyophilised plasma: Huisman EL, de Silva SU, de Peuter MA. Economic evaluation of pooled solvent/detergent treated plasma versus single donor fresh-frozen plasma in patients receiving plasma transfusions in the United States. Transfus Apher Sci. 2014 Aug;51(1):17-24. http://www.ncbi.nlm.nih.gov/pubmed/25151097
Lyophilised plasma: National Department of Health: Affordable Medicines, EDP-Adult Hospital Level. Price comparison analysis, updated: Fresh frozen plasma vs lyophilised plasma, September 2019. http://www.health.gov.za/