Amoxicillin/clavulanic acid IV is not suitable for intramuscular or subcutaneous administration.
- Amoxicillin/clavulanic acid, 1.2 g powder vials for intravenous injection containing amoxicillin sodium equivalent to 1 g of amoxicillin and potassium clavulanate equivalent to 200 mg clavulanic acid.
- Dosage Recommendation: Amoxicillin/clavulanic acid, 1.2 g, IV, 8 hourly.
- Directions for use:
- Powder vials for injection can be reconstituted by dissolving in 20 mL water for injection.
- Reconstituted vials can be administered intravenously by injection over 2 minutes or slow intravenous infusion over
- For intravenous infusion, the reconstituted vial should be further diluted with the desired volume of a suitable infusion fluid (e.g. Sodium chloride 0.9%, 100 mL).
- 30 minutes.
- The contents of the vials must be used within 20 minutes.
- Precautions:
- Allergy to penicillins.
- Drug-induced cholestatic hepatitis may occur, typically a few weeks after starting therapy. Use with caution in patients with evidence of hepatic dysfunction.
- Dosage adjustments required in renal impairment:
- CrCl >70 mL/minute: no dose adjustment required.
- CrCl 10–30 mL/minute: 1.2 g as a single dose followed by 600 mg 12 hourly.
- CrCl <10 mL/minute: 1.2 g as a single dose followed by 600 mg daily