| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
[26] Dantrolene, IV: Kolb ME, Horne ML, Martz R. Dantrolene in human malignant hyperthermia. Anesthesiology. 1982 Apr;56(4):254-62. https://www.ncbi.nlm.nih.gov/pubmed/7039419
Dantrolene, IV: Flewellen EH, Nelson TE, Jones WP, Arens JF, Wagner DL. Dantrolene dose response in awake man: implications for management of malignant hyperthermia. Anesthesiology. 1983 Oct;59(4):275-80. https://www.ncbi.nlm.nih.gov/pubmed/6614536
Dantrolene, IV: Larach MG, Brandom BW, Allen GC, Gronert GA, Lehman EB. Cardiac arrests and deaths associated with malignant hyperthermia in north america from 1987 to 2006: a report from the north American malignant hyperthermia registry of the malignant hyperthermia association of the United States. Anesthesiology. 2008 Apr;108(4):603-11. https://www.ncbi.nlm.nih.gov/pubmed/18362591
Dantrolene, IV: Chapin et al. Medscape: Malignant Hyperthermia Treatment & Management, 28 November 2018. [Internet][Accessed 2 December 2019] https://emedicine.medscape.com/article/2231150-treatment#d11
Dantrolene, IV: South African Medicines Formulary. 12th Edition. Division of Clinical Pharmacology. University of Cape Town, 2016.