| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
[8] Proton pump inhibitor, oral (H.pylori +ve): Leontiadis GI, Sharma VK, Howden CW. Proton pump inhibitor therapy for peptic ulcer bleeding: Cochrane collaboration meta-analysis of randomized controlled trials. Mayo Clin Proc. 2007 Mar;82(3):286-96. http://www.ncbi.nlm.nih.gov/pubmed/17352364
Proton pump inhibitor, oral (H.pylori +ve): Neumann I, Letelier LM, Rada G, Claro JC, Martin J, Howden CW, Yuan Y, Leontiadis GI. Comparison of different regimens of proton pump inhibitors for acute peptic ulcer bleeding. Cochrane Database Syst Rev. 2013 Jun 12;6:CD007999. http://www.ncbi.nlm.nih.gov/pubmed/23760821
Proton pump inhibitor, oral (H.pylori +ve): South African Medicines Formulary. 12th Edition. Division of Clinical Pharmacology. University of Cape Town, 2016.
Proton pump inhibitor, oral (therapeutic class): National Department of Health: Affordable Medicines, EDP-Adult Hospital level. Medicine Review: PPIs, therapeutic class review, April, 2018. http://www.health.gov.za/
Proton pump inhibitor, oral (therapeutic class): McDonagh MS, Carson S, Thakurta S. Drug Class Review: Proton Pump Inhibitors: Final Report Update 5 [Internet]. Portland (OR): Oregon Health & Science University; 2009 May. Available from http://www.ncbi.nlm.nih.gov/books/NBK47260/
Proton pump inhibitor, oral (therapeutic class): National Institute for Health and Care Excellence: Clinical Guidelines: Gastro-oesophageal reflux disease and dyspepsia in adults: investigation and management. https://www.nice.org.uk/guidance/cg184